A 19 yo F with a rash and progressive shortness of breath is found to have peripheral eosinophilia. Learn the differential of this abnormal lab finding.
70 yo M with fever and a red and swollen hand is found to have significant lab abnormalities. Learn the differential and evaluation of this lab abnormality.
This chalk talk reviews different types of transfusion reactions and initial evaluation of a patient with a suspected transfusion reaction.
A case of a 70 M who develops acute onset dyspnea after a platelet transfusion. Learn about different transfusion reactions and their initial management.
CASE: A 30 yo F with no significant PMH presents with fatigue and was found to have a hct of 18% and platelets of 9. Her coagulation panel was normal, LDH elevated and haptoglobin was low. A peripheral smear below shows:
What does the above image show?
The above peripheral blood smear shows evidence of schistoctyes.
What disorders as also associated with schistocytes?
Schistocytes can be seen in the following disorders:
- Thrombotic microangiopathies (HUS, TTP)
- Prosthetic heart valve, VADs
- HELLP syndrome
- Less commonly, schistocytes can be seen in:
- HSCT or solid organ transplant patients
- Severe hypertension
- Systemic infection
She was diagnosed with TTP and was treated with high dose IV methylprednisolone x 3 days and plasmapharesis x 3 days. An ADAMTS13 level ultimately came back at 0%, consistent with ADAMTS13 deficiency or hereditary TTP. She was maintained on FFP transfusions as an outpatient.
A 21 yo F presents with new petechiae and is found to have severe thrombocytopenia. Learn about the differential and evaluation of thrombocytopenia.
A 30 yo F presents with nausea, vomiting and diarrhea and is found to have severe anemia and thrombocytoepnia. Learn the diagnosis of these abnormalities and how to manage a mystery diagnosis.
A 70 yo M with asthma presents with SOB and WBC of 142k. Review his blood smear and CXR and learn how to manage this mystery diagnosis and its associated complications.